Epithelial Cell Signaling and Secretion Research Group
HCEMM-USZ Molecular Gastroenterology Research Group

Epithelial cells are essential orchestrators of organ physiology in the gastrointestinal tract, but impaired epithelial function or malignant transformation is associated with severe diseases with high mortality. Among the different GI disorders inflammatory and malignant diseases of the pancreas emerge due to their therapeutic difficulties, potentially lethal outcome and thus their social burden. Therefore our lab seeks to understand how epithelial cells sense physiological stimuli and stress factors and how they integrate and transduce these signals to physiological or pathological responses. We believe that our work will provide significant understanding of multiplex epithelial functions in physiology and pathophysiology, which shall have significant multidisciplinary and translational consequences and will help to develop novel therapeutic approaches to treat inflammatory and malignant diseases.